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Due to change in size and shape, the movement of red blood cells from bone marrow to the bloodstream become ineffective, often leading to megaloblastic anemia

These findings are also consistent with the low risk of abuse for tesofensine, as it has been reported to be unlikely to be abused recreationally [60]

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In research labs, it is mainly used to study NNMT activity, including inhibition experiments and enzyme activity assays

Furthermore, a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects was conducted