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Suppose the concentration of the formulation (say nanoparticles) is 10 mg/mL, its AED is 62 mg/kg, the rat weight is 250 g and is administered through intraperitoneal route, and then the injection volume is calculated as The injection volume observed here (1.55 mL) is well below the maximum injection volume (510 mL) for rat through intraperitoneal route and the injection site is lower left quadrant [Table 3]

Others rely primarily on injections with periodic infusions for deeper support

doi: 10.1210/en.2003-0973

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These numbers are provided for research-use-only reference and are not medical or dosing advice