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In the late stage of sepsis, macrophages will release high mobility group protein B1 (HMGB1), which can stimulate the expression of Sesn2 in DCs (82)

This binding domain was validated by ChIP-qPCR, which was qualitatively confirmed by agarose gel electrophoresis (Fig

For patients in the earlier stages of the disease, other treatments like oral levodopa, dopamine agonists, or MAO-B inhibitors may be sufficient

doi: 10.1096/fj.201800935RR 57 LongSLGahanCGMJoyceSA

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