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Studies have shown that Harmine significantly induces ferroptosis in OC cells SKOV3 by downregulating ferroptosis inhibitors such as SLC7A11/xCT, NRF2, and GPX4, promoting Fe + accumulation, LPO, and ROS generation
The brain with high cerebral metabolic rate, unsaturated fatty acids and iron content, and an inefficient antioxidant system, is highly susceptible to oxidative stress [125]
10.1186/s40643-021-00443-w 68 HopeL.BaileyJ
doi: 10.1016/j.celrep.2020.02.013 239 DuschaAGiseviusBHirschbergSYissacharNStanglGIEilersEet al
55(6): 81825 Wurthwein G, Koling S, Reich A, et al
