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Computational identification of genesocial environment interaction at the human IL6 locus

Within the tryptophan metabolic axis, efferocytosis drives an IDO1-dependent tryptophan-kynurenine metabolic flux in macrophages, activating the aryl hydrocarbon receptor (AhR) to promote inflammation resolution and tissue repair (146)

Moreover, OA is characterized by the phenotype of osteophyte formation, cartilage degradation, synovitis, and subchondral bone remodeling (Lieben, 2016)

found that the abnormal accumulation of double-stranded DNA in the cytoplasm may bind to the cytoplasmic DNA sensor (cGAS), thereby specifically triggering the STING-interferon (IFN) signaling pathway in microglia, promoting the expression and secretion of inflammatory cytokines

Carnitine exists in several forms, but not all of them cross the blood-brain barrier