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Cardiac, neurological, and retinal toxicity as well as increasing parasite resistance to these drugs is a major hindrance for their use in a world that is already dealing with antimicrobial resistance (AMR)

We found that ADA2-deficient Jurkat cells showed elevated levels of reactive oxygen species (ROS) compared with the WT-expressing cell line (Fig

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doi: 10.1055/s-0043-1776315 [DOI] [PMC free article] [PubMed] [Google Scholar] 31.Cone AS, Yuan X, Sun L, et al
