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Histologically, it shows lentiginous melanocytic hyperplasia and a skipped prominent basilar pigmentation that can focally extend to the stratum spinosus and corneum (31)

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doi: 10.1371/journal.pone.0082563 33 SrinivasGVNamalaSAnanthaneniAPuneethHKDeviBS

In the mid-2000s, Google recruited Buffenstein for its newest venture, Calico Life Science, where scientists of all stripes would work to plumb the biology of aging and develop drugs to combat it

Recent research has also indicated an important role for vitamin C in regulation of DNA and histone methylation by acting as a cofactor for enzymes which hydoxylate these epigenetic marks [22]