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You could have an underlying allergy, a chronic condition, or an autoimmune issue

If your Vitamin B12 levels are low, we recommend 8-10 Vitamin B12 injections over the first two to three months and then one per month for maintenance after that

Thus, in situ produced microbial folate may favourably influence the cellular nutrition of the local colonocytes and may be important in maintaining intestinal homeostasis and modulating gut microbiome function, e.g., through regulation of colon mucosal proliferation (i.e., colorectal cancer prevention) and its anti-inflammatory effects 248,249,256,257,277,278,279,280,281,282,283,284,285,286

Given the many unknowns with high dose folic acid supplementation, particularly unmetabolized folic acid (as covered in my folate article), Im not able to draw any strong conclusions here

Markers of bone turnover for the prediction of fracture risk and monitoring of treatment: a need for international reference standards. Osteoporosis Int , 2011.