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As we discussed in a review published in 2016 [74] , it is possible that these conflicting results arose from critical differences in experimental design, particularly in the use of different muscle injury models, and differences in the dosage and bioactivity of the particular rGDF11 molecule that was administered in each study

these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1

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Ipamorelin and CJC-1295 Growth Hormone Optimization Ipamorelin is a selective growth hormone secretagogue a peptide that stimulates the pituitary gland to release growth hormone in a physiological, pulsatile pattern that mimics the natural release patterns of youth