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doi: 10.1111/jcmm.15954 177 ZhaoHShiLWangXYuXWangD

The protective and therapeutic effect of cysteine precursors such as methionine and N -acetyl cysteine in patients and animal models of acquired 5-oxoprolinemia and 5-oxoprolinuria is probably related to restoration of both cellular cysteine stores and glutathione

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This theory was first experimentally confirmed in the 1980s by the laboratory of Eric Newsholme (19352011, widely accepted now as the origin of hypotheses and evidence for the concept of immunometabolism) [3,7] in the University of Oxford, and subsequently by many other laboratories worldwide [4,8,9]