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Although administration of low doses of sulfide donors at the time of or after reperfusion can activate several cytoprotective signaling cascades and attenuate reperfusion injury, slight overdose or delayed administration is often ineffective or harmful [58, 59, 85, 88]

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This profile is further shaped by genetic predisposition, initial microbial exposure at birth, and long-term dietary habits (209)

Bile acid metabolism: Gut bacteria convert primary bile acids into secondary metabolites that regulate cholesterol homeostasis and lipid absorption [19]