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For example, in the DiRECT study of people with obesity and diabetes, very severe caloric restriction leading to a loss of 15% of body weight led to complete remission of type 2 diabetes in 85% of participants

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L.BergoniaH.et al (2023)

Furthermore, the Keap1/Nrf2/ARE pathway exerts regulatory control over GSH levels by upregulating essential enzymes involved in GSH synthesis (54)

For example, 2DG mediated an increase in Galectin-3 and CD206 which are known to play distinct but complementary roles in phagocytosis, and in immune regulation and tissue homeostasis 61,62