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1 Introduction Transporter proteins mediate the import or export of nutrients, metabolic products, and other small molecules through equilibrative and concentrative transport across the membranes

4 However, the reported prevalence of DN varies significantly across studies, ranging from 6% to over 60%

In the following sections, for clarity LCACs are described as altering specific components of cardiac ECC

1 Introduction 1.1 Relationship among gut microbiota, TMA and TMAO production, and human diseases Consolidated literature from over the last 20 years confirms the relationship between intestinal microbiota and a series of diseases (Sorboni et al., 2022)

However, a case report study, a review study, and articles published in languages other than English were excluded from this review