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No longterm human trials exist

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, close monitoring for cholelithiasis is recommended during weight loss therapy, regardless of modality

I am unsure the reasoning of the timeframe recommendation

We recommend AOD-9604 to help with the early stages of weight loss while simultaneously building healthy habits that promote long-term weight maintenance.

The complex interplay of its active compounds, particularly arctigenin and flavonoids, warrants further investigation to fully understand their mechanisms and optimize AL's use in traditional and modern medicine for enhancing health outcomes