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Chen P, Mamillapalli R, Habata S, et al

Mechanistically, TRF inhibited the expression of epidermal E-cadherin, resulting in the increased nuclear translocation of -catenin and its interaction with Tcf3

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Laboratory research demonstrates that FOXO4-DRI's selectivity stems from exploiting fundamental differences between senescent and healthy cell biology, particularly the paradoxical state where senescent cells are primed for apoptosis but protected by specific survival mechanisms

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