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Pregnancy, breastfeeding, kidney disease, severe anemia, and neurologic symptoms may require closer follow-up

It also influences insulin regulation, which is crucial for managing body weight and fat storage

For example, sugar alcohols like sorbitol or mannitol (used in some chewable or effervescent preparations) can have osmotic effects, drawing water into the intestinal lumen and potentially leading to loose stools in sensitive individuals

Of course, all three causes can also work in combination

Overall, preclinical studies have shown that NAD + and mitochondrial metabolism play a crucial and intertwined role in aging and age-associated diseases, as well as being possible therapeutic targets for ameliorating these conditions