differential diagnosis of oral melanotic macule pigmented lesions: Clinicopathologic features and review the literature Pigmented Lesions | Pocket Dentistry
Description
Lipo-C commonly contains ingredients such as methionine, inositol, choline, L-carnitine, and B vitamins, which are involved in metabolic and cellular energy pathways

(c): data represented as box-whisker plot

Its pathogenesis is not known, but it is speculated that nevus of Ota is caused by faulty migration of melanoblasts from the neural crest to the skin

however, they are otherwise open or vesicular in appearance, and they lack the coarse anaplastic features typical of malignant cells

Doubling the dose doesn't compensate for the gap and increases the risk of methionine overload
