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Furthermore, silk fibroin itself exhibits therapeutic effects, such as attenuating spatial learning and memory impairments and preventing neuronal damage in A 25 35 -induced rat models through the reduction of Tau hyperphosphorylation and suppression of neuroinflammation (Yao et al., 2022), and preventing A- and/or reactive oxygen species-induced inflammation and apoptosis, along with improved cognitive function by increasing acetylcholinesterase (De Giorgio et al., 2024)

Clinical Benefits Promotes delta wave activity and deep sleep stages where the most restorative physiological processes occur including physical recovery, immune optimization, and metabolic regulation

Next, we performed two rounds of finer 3D classification by using local search in combination with small angular sampling, resulting in a new class showing improved density for the entire protein