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These studies suggest that CIPN is partly caused by (1) brain hyperactivity, (2) reduced GABAergic inhibition, (3) neuroinflammation, and (4) overactivation of GPCR/MAPK pathways

Incorporating sex as a biological variable in future studies will therefore be essential to determine whether males and females may benefit differently from antioxidant-based treatments and to address the current imbalance in ASD research