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Peripheral and central lipid dysregulation impairs mitochondrial function, alters the brain microenvironment, and initiates neuroinflammation, establishing a vicious cycle that exacerbates depressive pathology
For example, in African populations, fatigue was the most common symptom (26-56%), followed by confusion or lack of concentration (12-68%) and dyspnea (12-38%)
Mitophagy is processed mainly via Parkin ubiquitination and BNIP3-NIX-FUNDC1 mitochondrial adaptor pathways
Neutrophil extracellular trap cell death requires both autophagy and superoxide generation
