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Inflammopharmacology 2013;21(3):203-211

M1 macrophages (treated with LPS) have two points of substrate flux deviation with regards to the TCA cycle (in contrast to M2 macrophages) one occurring at the isocitrate dehydrogenase step and another post-succinate formation

4.3Role of portal hypertension in intestinal permeability While there are similarities in the molecular events in IBD and chronic liver diseases, portal hypertension is a typical feature of decompensated liver cirrhosis and a main driver of the systemic inflammation associated with liver cirrhosis, and it can occur in IBD [98]

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