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Further evidence supporting the existence of such a pathway in humans comes from imaging studies showing blood oxygen-level dependent (BOLD) responses in the pulvinar (LP/Po area in the posterior thalamus of the rat) of patients undergoing a migraine attack with extra-cephalic allodynia (47), and from diffusion MR tractography showing direct connections from the optic nerve to the pulvinar, and from the pulvinar to several associative cortical brain regions (48)

Thus, while further human trials are essential, it remains to be seen to what extent BPC 157a compound with primarily preclinical support, a wide range of pleiotropic effects, and no observed LD in toxicology studies [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]can truly achieve such outcomes through pharmacological means

A deeper understanding of these relationships will undoubtedly lead to more effective and personalized treatment strategies for those struggling with acne and other skin conditions