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[18] One result of frataxin deficiency is mitochondrial iron overload, which damages many proteins due to effects on cellular metabolism
In infants it is supposed that maternal androgens are responsible
IGF1 can reduce blood glucose levels and has been used to treat patients with type 1 and 2 diabetes This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 186,36 per year only 15,53 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF
Moreover, no formal weighting of individual studies was applied, and all data were considered equally regardless of evidentiary strength
On its external pathway, the ligands and cell death receptors such as FAS, TNF-R, linker proteins, caspases-3, -6, -7 and -8 are involved
