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doi: 10.1038/s41420-022-01199-8

While traditionally, studies have concentrated on assessing PDE5 expression within several human tissues, very recently, it has been demonstrated that it is possible to dose PDE5 not only in the penis but also in the peripheral blood [39]

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k , Glucose tolerance test on day 4

2.1.5 Phenotypic and functional features of scar-associated macrophages Scar-associated macrophages (SAMacs) represent a distinct macrophage state within fibrotic lung tissue, originally defined by high expression of CD9 and TREM2 and further characterized by co-expression of SPP1 ( + and TREM2 + macrophage subsets discussed above, they are distinguished by their stable localization within fibrotic niches, rather than by marker expression alone