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doi: 10.1155/2013/767482
Sirt3 deficiency shortens life span and impairs cardiac mitochondrial function rescued by Opa1 gene transfer
Noteworthily, the A 142 oligomers prepared in the presence of Semax or/and Cu 2+ (see Materials and Methods) show a significant effect on cell viability, reducing toxicity by more than 22% in the case of Semax alone and 20% in the case of Semax with Cu 2+
This is due to the elevated cellular vulnerability to oxidative stress and reactive oxygen species (Gawryluk et al., 2011)
Bastian SE, Walton PE, Wallace JC, Ballard FJ
