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Step 6 After donating its methyl group, SAMe becomes homocysteine again and the cycle repeats

[6] [8] Treatment [edit] The vast majority of people with aphthous stomatitis have minor symptoms and do not require any specific therapy

This research includes both animal models and human clinical trials
8th Machine Learning for Healthcare Conference 846862 (PMLR, 2023)

But Don't Discount the Systemic Argument Entirely Now, this is where the nuance comes in