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NETosis ROS induce NETosis through both NOX-dependent and NOX-independent mechanisms

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Additionally, this can inhibit the FAO response, which can enhance lipotoxicity

doi: 10.1038/s42003-023-05662-9

Moreover, either heme-Fe(II) or heme-Fe(III) can exhibit peroxidase activity (FIGURE 5, reactions VIIIX ), which produces an oxo-ferryl intermediate, Fe(IV)=O (62), that can generate oxygen radicals, Fe(III), and water (27, 63, 64)
