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The high reactivity of HNE results from the diminished electron density around carbon-3 of HNE as a consequence of two factors: 1 ) the resonance between the C=C of carbons-2 and -3 and the C=O bond of the aldehyde functional group on carbon-1 and 2 ) the inductive effect of the more electronegative O atom on the OH group of carbon-4 with the electrons around carbon-3

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Marnett LJ2002Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous SystemToxicol

ClinicalTrials.gov Identifier: NCT04634227