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Then, theres the muscle itself

Neither hindlimb nor forelimb skeletal muscle morphology or function were significantly affected by the loss of AR in mesenchymal progenitor cells, as indicated by maintained grip strength, absolute mass, fiber diameter, myofiber count, SC count, or fiber type proportions between transgenic and wild-type (WT) mice at 12-weeks of age

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A more recent work by Torres-Alemans group, elegantly demonstrated that this process is initiated by the release of glutamate at active regions, triggering two secondary processes: a vasodilation to increase local serum IGF-I availability and an increased activity of matrix metalloprotease 9, together with cleavage from IGFBP-3

The chaperone-associated complex is then translocated to lysosomes and imported by LAMP-2A for degradation