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Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer

doi: 10.1152/ajpcell.00558.2003

The anti-metastatic effects of berberine are mediated through the regulation of multiple signaling cascades, including MAPK, PI3K-AKT, and NF- B pathways [205, 220, 229, 231, 238, 241, 244, 245]

However, the addition of exogenous GSH reduced activities of the PA synthesis-enzymes like arginine decarboxylase (ADC), S-adenosylmethionine decarboxylase (SAMDC), and diamine oxidase (DAO), while increased the activities of polyamine oxidase (PAO) and ornithine decarboxylase (ODC), resulting in reduced levels of PAs such as Spd, Spm and Put

Chakrabarti, P., English, T., Shi, J., Smas, C
