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Crit Rev Food Sci Nutr

10.1093/humupd/dmv021 36 GamulinO.SerecK.BiliV.BalarinM.KosoviM.DrmiD.et al (2013)

That number rises to 1 in 5 in the over-60 population
Unknown long-term effects : Because human studies are extremely limited, we simply do not know whether prolonged use carries risks

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