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The use of nutritional supplements for children with DS is a topic that is extremely important for parents and caregivers as they want to improve their child's cognitive functions and health

Preclinical studies have demonstrated that antibiotic treatment induces gut dysbiosis-marked by reduced alpha diversity, a decreased Firmicutes/Bacteroidetes ratio, depletion of beneficial genera, and enrichment of pro-inflammatory taxa (Tejkalov et al., 2023

Accordingly, diverse BTKi are currently under study for both RRMS and PPMS in ongoing clinical trials, the most advanced ones being evobrutinib and tolebrutinib (184)

10.1002/advs.202004555 77 ZhangY.ZhangZ.WangH.CaiN.ZhouS.ZhaoY.et al (2016)