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MEN1, a key driver of pancreatic neuroendocrine tumors (pNETs), suppresses SCD1 expression by inhibiting mTOR, resulting in a decrease in MUFAs such as oleic acid (OA) and ultimately promoting lipid peroxidation and ferroptosis in pNETs

These observations provide preliminary evidence for the interplay between histone modifications and RNA epigenetics in cancer progression, although further studies are required to confirm these mechanisms [76]

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