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A well-characterized example is ezatiostat (TLK199)a GSH peptidomimetic moleculedesigned to display enhanced cellular uptake and whose metabolites bind the G-site of GSTP1-1 causing enzyme inhibition

Preclinical research suggests involvement in biological processes (angiogenesis, collagen formation, cellular signaling), which are linked to tissue healing and inflammation control

Moreover, high ROS concentrations and inflammatory mediators in chronic inflammatory environments may disrupt the Ce 3+ /Ce 4+ balance, impairing its enzyme-mimetic activity and thereby restricting sustained ROS elimination [80, 83]

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Acetaminophen overdose is the leading cause of acute liver failure in the developed world (Larson 2005