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VNS has been demonstrated to effectively enhance the Nrf2/HO1 signaling axis, bolstering the kidney's endogenous antioxidant defense mechanism and mitigating oxidative damage (Deng et al

DHAR breaks DHA to ascorbic acid, utilizing reduced GSH, which is critical for maintaining sufficient ascorbate levels

Direct Adrenergic Agonism: Ephedrine is also able to directly bind to multiple post-synaptic adrenergic receptor subtypes to initiate intracellular signaling cascades: : Activation of vascular smooth muscle 1 -Adrenergic Activation 1 -adrenergic receptors produces arterial and venous vasoconstriction, leading to an increase in systemic vascular resistance (SVR), diastolic blood pressure, and systolic blood pressure (Solanki et al, 2014)

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