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We therefore reevaluated the PIF4 TAD with the improved mechanistic predictor of acidic TADs that tallies four charged residues (D, E, R, K) and three hydrophobic residues (W, F, L) 70

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Schirbel A, Rebert N, Sadler T, West G, Rieder F, Wagener C, et al

Therefore, it has been widely used to create various dosage forms, including oral, injection, transdermal, and pulmonary delivery, and has broad prospects in developing new drugs for AD