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For example, tyrosinase, which catalyses the production of melanin, is a copper-containing enzyme and lack of catalytic activity contributes to the hypopigmented hair seen in classical Menkes

Diclofenac was found to be more toxic in drug metabolizing cells (isolated primary hepatocytes) compared to non-metabolizing cells (HepG2, FaO)
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doi: 10.1136/bjsm.2004.012526 87

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization

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