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Altered LDH expression impacts neuronal excitability and synaptic function [297]

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However, the adjuvant use of probiotics shows a positive correlation between changes in LPC (18:0) and Young Mania Rating Scale (YMRS scale), and in addition, the mania symptom greatly ameliorated in patients who received probiotic supplements as compared with the placebo

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Abbreviations AD: Alzheimers disease ANS: Autonomic nervous system BBB: Blood brain barrier CNS: Central nervous system GABA: Gamma aminobutyric acid NF-B: Nuclear factor kappa B NLRP3: Nod-like receptor pyrin 3 PD: Parkinsons disease ROS: Reactive oxygen species SAH: S-adenosyl-homocysteine SN: Substantia nigra References Aborode AT, Pustake M, Awuah WA, Alwerdani M, Shah P, Yarlagadda R, Ahmad S, Silva Correia IF, Chandra A, Nansubuga EP, Abdul-Rahman T, Mehta A, Ali O, Amaka SO, Zuiga YMH, Shkodina AD, Inya OC, Shen B, Alexiou A (2022) Targeting oxidative stress mechanisms to treat alzheimers and parkinsons disease: a critical review