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Of note, CTP:phosphocholine cytidylyltransferase (CCT), the rate-determining enzyme in de novo synthesis of PC, was less expressed in IECs from Apc +/Min /Stard7 IEC mice, possibly as a result of PC accumulation in the ER due to a defective transfer to mitochondria (Fig

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DN is a multifactorial complication involving hyperglycemia-induced intracellular stress, dyslipidemia, oxidative damage, immune dysregulation, and chronic inflammation (Yang et al., 2025
