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The term was given by Werdnig and Hoffmann (DAmico et al., 2011), and the disease could be recognized by the development of symptoms of weakness in one arm and/or one leg as well as facial weakness, numbness or tingling, difficulty in swallowing or speaking, trouble walking and balancing, and gradual memory loss

These dual effects synergistically promote drug tolerance in DTPs by enhancing survival pathways and mitigating oxidative stress