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[47] The importance of regulating the conversion of pyruvate into acetyl-CoA is also underscored by the fact that mammals, although able to produce glucose from pyruvate, cannot synthesize it from acetyl-CoA because of the irreversibility of the pyruvate dehydrogenase reaction and the absence of alternative pathways

10.1016/j.cocis.2013.07.001 113 RheinstdterM

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Research highlighted TA's role in reducing white adipose tissue expansion and promoting brown adipose tissue activation to regulate obesity