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Guyatt GH, Oxman AD, Vist GE, et al

A telomere shortening effect of IL-1 has already been observed as a result of faster cell turnover influenced by increased baseline inflammation 30

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Hepatic clearance of rat liver aspartate aminotransferase isozymes: evidence for endocytotic uptake via different binding sites on sinusoidal liver cells

Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation