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FSP1-CoQ10-NAD (P) H signaling pathway acted synergistically with GPX4 and GSH to inhibit lipid peroxidation and ferroptosis (Schointuch et al., 2014)

The thiol group is important this sulfur compound allows glutathione to donate electrons to neutralize reactive oxygen species ( ROS ) in the cell

As discussed in Section 2.3, this pathway is influenced by oxidative stress and plays a protective role in the acute phase by promoting cardiomyocyte survival and upregulating anti-apoptotic and antioxidant proteins (Liu P

Krat Yalva

Notably, in this study, vitamin D appears to influence the development of pulmonary fibrosis through multiple biological pathways: vitamin D deficiency not only exacerbates the lung inflammation caused by bleomycin (similar to the effect observed in the case of vitamin C deficiency), but also increases the likelihood of the occurrence of EMT in the lungs, and these are all crucial steps in the pathogenesis of pulmonary fibrosis