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10.1016/j.biopha.2024.116160 153 VermaM.RhodesM.ShintonS.WiestD

Overexpression of hHPN WT in hepsin / mice significantly increased their tolerance to APAP, as evidenced by a marked reduction in liver degeneration area and APAP-cysteine adduct levels at 2 h post-APAP injection compared to the two control groups (Fig

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In addition, the expression of GPX4, HCFC1R1 and MYC was higher in R group tumors, although the statistical significance was marginal (Supplementary Fig

These results indicated that NAC treatment did not significantly alter the relative levels of PI3K and AKT expression, but significantly increased the relative levels of PI3K and AKT phosphorylation in TSPCs, which were abrogated by treatment with LY294002