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High concentrations of ascorbic acid can destabilize copper peptides, reducing their effectiveness

doi: 10.1038/cdd.2013.108 159 TakataMNakagomiTKashiwamuraSNakano-DoiASainoONakagomiNet al

Nicolay, J

74 Chronic overnutrition, a sedentary lifestyle and IR in adipose tissue can directly lead to the production and accumulation of excess toxic lipid products (such as diacylglycerol, ceramides, and NEFAs), and the metabolites can aggravate the ectopic lipid deposition through some signaling pathways (such as mTOR and notch)

GPX1, 2, 3, 4 and 6 carry a highly reactive selenocysteine residue in their active site that is crucial for enzymatic activity and the efficient reduction of membrane hydroxy peroxides into their alcohol counterparts