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The ineffectiveness of conventional antioxidants in reducing the severity of ROS-related diseases may be due to their inability to accumulate within mitochondria, where free radical generation is most intense

autonomic sympathetic neurons , brain tissue & and transports monoamines (dopamine, norepinephrine, serotonin & histamine) from the cytoplasm into presynaptic storage vesicles Binds to the same site on VMAT1 & 2 as intracellular monoamines, producing a strong long-lasting inhibition of monoamine (e.g

Acyl-Glutathione: The bodys master antioxidant and essential building block of skin that targets visible signs of aging, including wrinkles and creases, by replenishing fragile skin

It creates a chronic pro-oxidant environment that overwhelms the already-depleted GSH-based antioxidant network in diabetic patients