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Description
These findings are supported by animal studies, where Mn overexposure reduced heart rate, decreased cardiac contractility, and also led to ECG abnormalities (Jiang et al., 2005)
Specifically, SHRSP on high-salt diet (also called permissive diet) develop severe BBB disruption, white matter vacuolization, microbleeds and a thrombotic microangiopathy, that are reversible upon switching to regular diet and implementing antihypertensive treatment (411)
31 GeorgeS
Khalil E
Immunity 30 , 646655 (2009)
