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Insulin resistance is correlated with high cholesterol synthesis and decreased cholesterol absorption in men (254)

doi: 10.1038/nn.2270

1,15 Hyperglycemia-induced metabolic pathways Polyol pathway activation In a hyperglycemic state, excess glucose is shunted into the polyol pathway, where aldose reductase catalyzes its reduction to sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase

In healthy populations with adequate levels, the evidence tends to be more heterogeneous, so absolute conclusions should be avoided

Effects of Aerobic-, Anaerobic- and Combined-Based Exercises on Plasma Oxidative Stress Biomarkers in Healthy Untrained Young Adults