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Schweiz Rundsch Med Prax 2001 May 10

Notably, we found that the AC-like cell state is lost with serial passaging in patient derived cell models and xenografts, due to selection for more proliferative populations and due to transformation towards a mesenchymal phenotype

But you've reduced effective dose by nearly half through timing alone

An organism that can simply sequester its vitamins from the environment may therefore be at an evolutionary advantage, as the process of endogenous enzymatic de novo synthesis of these compounds would have entailed a disadvantageous cost in terms of energy expenditure, the need for cellular machinery, and the oxidative stress involved in metabolism [3,4]

Black sorghum is especially considered a high-antioxidant food and had the highest anthocyanin content of all in the study, while white-grained sorghum has been found to have a high polyphenol content