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If this beneficial effect and resolving adequately the anatomical imbalance in venous drainage would not occur, centrally, a harmful inability to drain venous blood adequately for a given cerebral blood inflow without raising venous pressures, suddenly goes to such venous and intracranial hypertension [60,61,62,63,64], as seen in the controls with the permanently occluded superior sagittal sinus

MTHFR itself is not linked to reduced life expectancy, but the health risks associated with elevated homocysteinesuch as heart disease and strokecan affect longevity if left unmanaged

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10.1038/nprot.2015.082

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